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3 Widely Used Drugs Classified as 'Carcinogenic' by WHO Research Agency: Risks, Therapeutic Effects, and the Way Forward
General Studies Paper – II: Governance, Constitution, Polity, Social Justice, and International Relations.
Context
In its recently released evaluation (Monograph Volume 137), the International Agency for Research on Cancer (IARC), the cancer research agency of the World Health Organization (WHO), has classified three highly prevalent drugs Hydrochlorothiazide, Voriconazole, and Tacrolimus as "carcinogenic to humans" i.e., in Group 1. All three drugs are included in the WHO Model List of Essential Medicines and are used by millions of patients worldwide. This report is a detailed and official expansion of the preliminary findings published in The Lancet Oncology in November 2024.
Three Major Drugs Classified as Carcinogenic
According to the scientific evaluation by IARC, the uses of these drugs and the evidence of specific cancers associated with them are as follows:
- Hydrochlorothiazide:
- Use: A thiazide diuretic used in the treatment of high blood pressure and swelling/edema.
- Risk and Evidence: According to IARC, there is sufficient evidence that it causes squamous cell skin carcinoma (skin cancer) and cancer of the lips.
- Voriconazole:
- Use: An antifungal medication used to treat severe and complex fungal infections.
- Risk and Evidence: Due to its phototoxic mechanism, it causes squamous cell skin carcinoma in organ transplant recipients undergoing long-term therapy.
- Tacrolimus:
- Use: A major immunosuppressant used to prevent rejection after an organ transplant.
- Risk and Evidence: It has been linked to non-Hodgkin lymphoma and post-transplant lymphoproliferative disorders. Additionally, limited evidence has been found for leukemia and skin carcinoma.
Why in the News?
Publication of IARC Monograph Volume 137: Official report released by WHO’s cancer research agency on August 5, 2026, issuing a global alert.
- Expert Warning and Risk Identification: Medical experts state that this classification is a 'hazard identification', but patients should not stop taking the medication immediately without medical advice.
- Special Concern for India: The risk is higher in a country like India due to irrational prescriptions, easy availability of over-the-counter (OTC) drugs, and weak adherence to ethical prescribing standards.
Indian Scenario and Experts' Perspective
According to Dr. Kabir Sardana, Director, Professor, and Head of the Department of Dermatology at Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia (RML) Hospital, New Delhi, the implications for India are extremely sensitive:
- High-Risk Geographical Regions and Groups: The risk of Hydrochlorothiazide has been observed to be particularly high in rural areas, northeastern states, hilly and coastal regions, and outdoor workers exposed to sunlight.
- Off-Label Prescription: Voriconazole is frequently being used for unapproved indications, such as treatment-resistant fungal infections caused by Trichophyton indotineae.
- Administrative and Diplomatic Challenges: The sale of over-the-counter medicines and the lack of ethical standards in drug distribution in India make it impossible to ignore these warnings.
Brief Description of Evaluated Drugs and Cancer Risk
Drug Name | Primary Therapeutic Use | IARC Classification | Associated Cancer / Health Risk |
Hydrochlorothiazide | High Blood Pressure | Group–1 Carcinogenic Substance | Squamous cell skin carcinoma and cancer of the lips |
Voriconazole | Severe Fungal Infections | Group–1 Carcinogenic Substance | Squamous cell skin carcinoma (via phototoxicity) |
Tacrolimus | Preventing Organ Transplant Rejection | Group–1 Carcinogenic Substance | Non-Hodgkin lymphoma, post-transplant disorders, leukemia (limited) |
Key Concerns and Challenges
Panic vs. Continuation of Therapy: Abruptly stopping medications by patients can increase the risk of heart attacks, organ transplant failure, or severe fungal infections.
- Irrational Use: Doctors in India prescribing high-end antifungals and immunosuppressants without necessity or in off-label cases.
- Environmental and Sun Exposure: In the Indian climate, exposure to high UV radiation (ultraviolet rays) further enhances the carcinogenic effect of phototoxic drugs.
- Lack of Regulatory Oversight: Laxity in the pharmaceutical regulatory framework to prevent the over-the-counter sale of medicines.
The Way Forward
Prioritizing Medical Consultation: Patients should not abruptly discontinue taking these essential medicines without consulting their physician.
- Considering Alternative Medications: Doctors should assess safer or lower-risk alternatives for the treatment of high blood pressure and fungal infections.
- Strict Pharmaceutical Regulation: Strict monitoring by the Central Drugs Standard Control Organisation (CDSCO) on off-label prescriptions and over-the-counter sales.
- Public Awareness and Sun Protection: Adopting protective measures against sunlight exposure for patients taking these drugs, especially outdoor workers.
Conclusion
The classification of these three essential drugs into the carcinogenic category by WHO/IARC is an important wake-up call for global public health. While this classification directs doctors to exercise greater caution and adopt rational prescribing practices, it is equally necessary for patients to maintain a scientific risk-benefit balance. India urgently needs to implement strict regulatory reforms and ethical drug distribution practices within its healthcare system.
Supreme Court's Tough Stance on Digital Arrest: A New Chapter Towards Cyber Security and Justice
General Studies Paper – III: Technology, Economic Development, Biodiversity, Environment, Security and Disaster Management.
Context
In today's digital age, while online services have made life easier, new forms of cybercrime have emerged as a serious challenge to public safety. In recent years, a new and alarming cyber fraud named 'Digital Arrest' has surfaced, which extorts the lifelong savings of ordinary citizens by putting them under severe mental pressure. Considering this growing tragedy, the Apex Court of the country has taken strong cognizance of the matter.
What is Digital Arrest?
'Digital Arrest' is a sophisticated cyber fraud in which fraudsters impersonate officers from police, Central Bureau of Investigation (CBI), Enforcement Directorate (ED), Customs, or other law enforcement agencies to call or video call victims (such as via WhatsApp or Skype). They falsely accuse the victim of being involved in illegal parcels, money laundering, or criminal activities. Subsequently, by instilling fear of legal action and arrest, the victim is kept under 'digital custody' on video call for hours or days, and large sums of money are extorted under the guise of settling the matter. However, legally speaking, there is no such statutory concept as "Digital Arrest" in India.
Reasons for Discussion
Supreme Court's Intervention: The Supreme Court has issued strict guidelines in this regard to the Central Government, States, Reserve Bank of India (RBI), and telecom authorities.
- Major Action by CBI: Taking action against this network, the CBI has currently registered 10 primary cases. In a single investigation, 238 victims, 67 first-layer bank accounts, and suspicious transactions of approximately ₹80 crore were uncovered, leading to raids at 93 locations across 16 states.
- Implementation of Strict New Rules: The Department of Telecommunications has notified the 'Telecommunications (Radio Equipment Possession Authorisation) Rules, 2025', while the 'Telecommunications (User Identification) Rules, 2025' is in its final stage.
- Inter-Agency Coordination: A data-sharing Memorandum of Understanding (MoU) has been executed between the Reserve Bank Innovation Hub and I4C.
- Financial and Mental Trauma: Continuous cases of fraud worth crores of rupees targeting senior citizens and professionals across the country are coming to light.
Strict Directives of the Supreme Court
The Honorable Supreme Court has issued the following detailed directives to curb this menace:
- Formulation of Standard Operating Procedure (SOP): The Central Government, States, RBI, and telecom authorities have been ordered to prepare an integrated SOP to deal with digital arrest.
- Restriction on Mule Accounts: The RBI has been directed to issue an SOP for banks within 4 weeks to immediately place a temporary debit hold on 'mule accounts' linked to cyber fraud and money laundering. A copy of this SOP will also be submitted to the Registrars General of the High Courts.
- e-Zero FIR and State Centres: All States and Union Territories have been directed to notify State Cyber Crime Coordination Centres and implement the "e-Zero FIR" system within 4 weeks.
- Time-Bound Money Restoration: Directions have been issued to fully operationalize the mechanism for the time-bound restoration of financial losses to victims.
Status Report and Statistics Submitted by I4C
To assess the effectiveness of the cyber security framework, the Supreme Court reviewed the fourth status report of the 'Indian Cyber Crime Coordination Centre' (I4C) working under the Ministry of Home Affairs (MHA). This report indicates that stringent steps are yielding positive results:
Key Statistics of the I4C Report:
Sharp Reduction in Complaints: Complaints related to digital arrest on the National Cyber Crime Reporting Portal were 1,23,672 in the year 2024, which dropped to 58,249 in 2025. Furthermore, as of June 30, 2026, this figure has declined to 16,377.
- Data Sharing Agreement: On May 11, 2026, a landmark data-sharing MoU was executed between the 'Reserve Bank Innovation Hub' and 'I4C'.
- Expansion of Banking Network: Presently, the grievance redressal portal covers 1,23,590 branches of 69 banks.
- Success in Money Restoration: 57 banks have joined the Money Restoration Mechanism Portal, and it is active across all 36 States/Union Territories. Through this, restoration has been completed in 36,290 cases, recovering an aggregate amount of ₹18.05 crore to the victims.
Major Steps Taken by the Government
The government has taken multi-pronged measures to curb digital arrest and cyber fraud:
- I4C and National Portal: Operation of the 'National Cyber Crime Reporting Portal' and helpline number 1930 by the Ministry of Home Affairs.
- Strict Telecom Rules: The 'Telecommunications (Radio Equipment Possession Authorisation) Rules, 2025' was implemented to curb fake SIMs and unauthorized communication equipment, and user identification rules are in the final stage.
- Introduction of e-Zero FIR: Currently, the 'e-Zero FIR' system is functional in 19 states, allowing victims to lodge an online FIR immediately without jurisdictional concerns.
- Coordination in States: So far, 14 states have notified their dedicated 'State Cyber Crime Coordination Centres'.
- CBI and International Cooperation: Nationwide operations are being conducted by the CBI to dismantle cyber syndicates operating via the dark web and across international borders.
Analysis
The decline in digital arrest cases proves that institutional rigor and swift technological intervention can deter cybercriminals. However, given the evolving tactics of fraudsters, administrative efforts alone are not sufficient; continuous monitoring and institutional accountability will determine the true success of this justice delivery mechanism.
Way Forward
Public Awareness Campaign: A widespread media campaign should be launched to convey the message that "law enforcement agencies never conduct arrests via video call."
- AI-Based Fraud Detection: Banks and telecom companies should adopt AI-based real-time monitoring systems to block suspicious financial transactions and spoofed international calls.
- Strict Crackdown on Mule Accounts: KYC (Know Your Customer) rules in banks must be further tightened to dismantle the creation of 'mule accounts' right at the entry level.
- International Police Cooperation: Since many cybercriminals operate from abroad, it is necessary to strengthen extradition and cyber-intelligence partnerships with Interpol and foreign agencies.
Conclusion
The Supreme Court's firm stance on heinous cybercrimes like digital arrest, combined with the government's institutional framework, is guiding India towards a secure digital future. This convergence of public awareness, swift legal action, and robust technical security is essential to safeguarding the digital rights of every citizen.
Food Safety and Consumer Rights: FSSAI's Crackdown on '100% Purity' Claims
General Studies Paper – III: Technology, Economic Development, Biodiversity, Environment, Security and Disaster Management.
Context
Accurate and transparent classification of food items is essential for consumer protection and health security. In recent years, the prevalence of claims like '100% Natural' and '100% Pure' by FMCG companies to boost product sales has grown significantly. To protect consumers from misleading advertisements and to enforce food safety standards, the food regulator FSSAI has taken a stern step in this direction.
Key News Points
Recently, the 'Food Safety and Standards Authority of India' (FSSAI) issued a major order against FMCG giant Dabur India Limited:
- Ban on Products with '100%' Claims: FSSAI ordered Dabur to immediately recall food products from the market carrying labels such as '100% Pure', '100% Natural', '100% Organic', or '100% Tender'.
- Affected Products: The scope of this order includes Dabur's honey, apple cider vinegar, virgin coconut oil, sesame oil, cow ghee, coconut water, and coconut milk.
- Unauthorized Use of Jaivik Bharat Logo: Dabur's Organic Apple Cider Vinegar and Organic Honey were found displaying the 'Jaivik Bharat' logo without valid FSSAI organic endorsement.
- Violation of Compound Food Rules: 'Dabur Hommade Coconut Milk' was marketed claiming "100% Purity", whereas such claims on mixed or compound food items are completely prohibited under the rules.
- Compliance and Report: Following a lack of satisfactory corrective action despite a prior notice, the regulator directed the immediate halting of sales and the submission of an 'Action Taken Report' (ATR) within 15 days. Subsequently, Dabur's shares fell by approximately 4%.
Reasons for FSSAI Imposing the Ban
FSSAI cited the following technical and legal reasons in its order:
- Violation of FSS (Advertising & Claims) Regulations, 2018: Under the law, claims like '100%' are highly ambiguous, scientifically unverifiable, and likely to mislead consumers.
- Violation of FSS (Organic Foods) Regulations, 2017: Using an organic logo on a product without completing valid certification processes is illegal.
- Consumer Deception: The claim of '100% Pure' creates a false impression in the consumer's mind that the product contains no other ingredients, processing, or natural alterations, which is practically impossible in packaged food.
Impacts of this Action
Impact on Consumers: Transparent information will be available in the market, enabling consumers to make informed decisions rather than falling for misleading advertisements.
- Impact on Industry & Corporate Sector: Companies will need to re-evaluate their labeling practices and advertising campaigns. This has a direct financial impact on brand value and the stock market.
- Level Playing Field: Ethically operating businesses and genuine organic producers will get an opportunity for fair competition in the market.
Government Initiatives and Legal Provisions
The following legislative framework governs misleading advertisements and food standards in India:
- Food Safety and Standards Act, 2006 (FSS Act, 2006): This Act serves as the primary basis for regulating the manufacture, storage, distribution, and sale of food items.
- FSS (Advertising & Claims) Regulations, 2018: These rules lay down strict standards for any claim (health, nutrition, or purity) made in food advertisements.
- Consumer Protection Act, 2019 (CPA, 2019): Under this, the 'Central Consumer Protection Authority' (CCPA) was established, which can impose fines and take strict action against misleading advertisements and unfair trade practices.
- Jaivik Bharat Certification: An integrated logo authorized by FSSAI to prove the authenticity of organic food products in India.
Related Concerns and Challenges
Industry-wide Prevalence: 'Greenwashing' (projecting products as environmentally or health-friendly) and misleading claims are rampant not just in one company, but across the entire FMCG sector.
- Limitations of Regulatory Monitoring: Given the country's vast market and millions of food products, continuous real-time inspection of every product label remains a major administrative challenge.
- Protracted Legal Processes: Companies often gain time under the guise of judicial appeals or changing labels, reducing the immediate deterrent effect.
Analysis
FSSAI's stern action clearly underscores that consumer health and informational transparency take precedence over commercial interests. This step is a progressive effort toward aligning India's regulatory framework with international food safety standards.
Way Forward
Integrated Surveillance System: Greater inter-agency coordination is required between FSSAI, CCPA, and the Advertising Standards Council of India (ASCI) to enable multi-tiered review of advertisements.
- Stringent Penal Provisions: For repeated violations involving misleading claims, strict actions such as heavy financial penalties and license suspensions should be taken, rather than mere product recalls.
- Strengthening Digital & Lab Infrastructure: The network of state-of-the-art food testing laboratories should be expanded to enable swift scientific verification of food claims.
- Public Awareness Campaigns: Under 'Jago Grahak Jago', citizens should be educated on how to read and understand food labels.
Conclusion
This decision by FSSAI will prove to be a landmark moment in the history of consumer protection and corporate accountability in India. Until strict regulatory mechanisms are combined with an aware consumer culture, building a safe and integrity-driven food ecosystem remains impossible.
Glaw Lake: Arunachal Pradesh's First and India's 101st Ramsar Site
Context
Wetlands play a crucial role in maintaining ecosystem balance, water purification, flood control, and biodiversity conservation. To protect wetlands of international importance, an international treaty (Ramsar Convention) was adopted in 1971 in the city of Ramsar, Iran. Recently, India achieved a significant milestone in wetland conservation by increasing the number of Ramsar sites in the country to 101.
Key News Points
First Ramsar Site: Arunachal Pradesh's 'Glaw Lake' has been declared the state's first and India's 101st wetland of international importance.
- Official Announcement: The achievement was announced by the Union Minister of Environment, Forest and Climate Change.
- Expansion of Network: The number of Ramsar sites in India grew from 26 in 2014 to 101 in 2026, reflecting India's commitment to environmental protection.
Glaw Lake
Geographical Location: This lake is located within the Kamlang Tiger Reserve and Wildlife Sanctuary in the Lohit/Lower Dibang Valley region of Arunachal Pradesh.
- Water Source: The lake is fed by perennial mountain streams.
- Biodiversity Wealth:
- This area is home to exceptionally rich flora and fauna.
- More than 150 tree species and 49 orchid species are found here.
- Being a part of the Kamlang Tiger Reserve, it provides a safe natural habitat for tigers, snow leopards, clouded leopards, and endangered wildlife.
Other Major Northeastern and Indian Ramsar Sites:
Deepor Beel (Assam), Loktak Lake (Manipur - also included in the Montreux Record), Rudrasagar Lake (Tripura).
- Other Indian Sites: Chilika Lake (Odisha), Wular Lake (Jammu & Kashmir), Chandra Taal (Himachal Pradesh), Vembanad-Kol (Kerala).
Significance
- Boosting Conservation in the Northeast: Becoming the first Ramsar site in a biodiversity-rich state like Arunachal Pradesh will bring global recognition and encouragement to wetland conservation in the Eastern Himalayan region.
- Eco-Tourism and Local Livelihood: Receiving Ramsar site status will promote controlled eco-friendly tourism in the region and create sustainable livelihood opportunities for local communities.
- Water and Climate Security: Being a perennial high-mountain wetland, it helps maintain the regional water cycle and acts as a carbon sink.
Conclusion
Declaring Glaw Lake as a Ramsar site reflects the success of India's commitment to sustainable development and 'wetlands conservation'. Given the sensitivity of the Himalayan ecosystem, this step will prove to be a milestone in the long-term conservation of the unique biodiversity and water resources of Northeast India.